Can you create a second Express Entry profile?

Not while the existing one is still active. IRCC states that if you do, you will have to withdraw the existing profile first.

“Don't create a new profile until your existing profile expires. If you do, you'll need to withdraw your existing profile first.”

When this answer doesn’t apply

· It concerns Express Entry profiles. Provincial Nominee Program applications are separate submissions.

These are limits of the answer, not a judgment about any reader’s situation. Working out which apply is yours to do.

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